Ayyalasomayajula Lalitha, India's first female engineer (graduated 1943) from College of Engineering, Guindy (CEG), Chennai, is the most prominent pioneer. Other notable Tamil Nadu-based engineering trailblazers include ISRO project director N. Valarmathi and CSIR leader Dr. N. Kalai Selvi. These women overcame societal barriers to lead in electrical, civil, and aerospace fields.
- A. Lalitha (Ayyalasomayajula Lalitha) (1919–1979): Born in Madras, she was the first woman to graduate from CEG in 1943 with an electrical engineering degree. She worked on transmission lines for the Bhakra Nangal Dam.
- N. Valarmathi: Born in Ariyalur, Tamil Nadu, she is an ISRO scientist and was the Project Director of RISAT-1, India's first indigenously developed Radar Imaging Satellite.
- Dr. N. Kalai Selvi: A pioneering researcher who became the first woman Director General of the Council of Scientific and Industrial Research (CSIR).
- P.K. Thressia & Leelamma George Koshie: Alongside A. Lalitha, these women were part of the first batch of female graduates from CEG, Guindy in 1944.